Lyophilized Peptides
Tirzepatide Research Reference — 10 mg
LY3298176
A synthetic, lipidated peptide research reference characterized in published studies as a dual agonist of human GLP-1R and GIPR.
12604 in stock
For laboratory research use only. Not for human or veterinary use.
Lot documentation
Current Certificate of Analysis
25 approved certificates are attached to this product record.
Technical information
Chemical & material record
Presented in a scientific-catalog format so the material can be evaluated by identity, form and documentation before purchase.
- Identity
- Tirzepatide research reference
- Synonyms
- LY3298176
- CAS number
- 2023788-19-2
- Molecular formula
- C225H348N48O68
- Formula weight
- 4,813.5 Da
- Sequence / identity note
- 39-residue modified peptide; sequence controlled in the technical record
- Manufacturer
- Remetide
- Manufacturing role
- Custom peptide synthesis and manufacture
- Form
- Lyophilized, non-sterile research material
- Purity specification
- Target ≥99% by RP-HPLC; lot result controls
- Storage
- -20°C, dry and protected from light; follow lot documentation
- Pack size
- 10 mg
- Catalog number
- GT-PW-10MG
Research context
Published research & product context
Published literature is presented separately from lot-specific identity, purity and analytical results.
Tirzepatide (LY3298176) is a 39-residue modified peptide studied as an agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR). Published work has characterized receptor signaling, receptor internalization and downstream metabolic endpoints in non-clinical models.
In human receptor-expressing HEK293 systems, reported cAMP EC50 values were 6.54 nM at GLP-1R and 1.01 nM at GIPR; receptor internalization was also evaluated at 100 nM. These literature values are assay specific and are not release criteria for the supplied material.
Selected published findings
- Induced cAMP signaling in HEK293 cells expressing human GLP-1R or GIPR.
- Induced internalization of GLP-1R and GIPR in receptor-expressing cellular systems.
- Was evaluated in mouse models for metabolic and airway-response endpoints.
References and product citations 3
- Willard, F.S., Douros, J.D., Gabe, M.B.N., et al. Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist. JCI Insight 5(17), e140532 (2020).
- Samms, R.J., Coghlan, M.P., and Sloop, K.W. How may GIP enhance the therapeutic efficacy of GLP-1? Trends in Endocrinology & Metabolism 31(6), 410–421 (2020).
- Toki, S., Goleniewska, K., Zhang, J., et al. GIP receptor agonism suppresses allergic airway inflammation in obese mice. Journal of Allergy and Clinical Immunology (2023).
Literature interpretation: This summary describes published experimental literature and is not a lot specification, clinical claim, use instruction or representation that the supplied research material will reproduce a published result. This record intentionally excludes dosing, administration, clinical outcomes, patient eligibility and therapeutic comparisons.
Intended laboratory context
Illustrative applications
- Analytical method development
- Identity comparison
- Qualified receptor-assay research
- Controlled non-clinical laboratory investigation
Documentation package
Documentation
- PDFIllustrative Certificate of AnalysisSample
- PDFHPLC chromatogramSample
- PDFMass-spectrometry summarySample
- PDFMaterial handling statementSample
Not for clinical, diagnostic, compounding, therapeutic, human or veterinary use. Current labeling, specification and lot documentation control.
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Documentation before decision-making.
Reference GT-PW-10MG and the applicable lot when contacting technical support. Published files support evaluation but do not replace the approved lot COA or material specification.
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