Reported 2026-10-13Lot MS10-100826-199.09% purity · 12.80 mg
Open COA
Lyophilized Peptides
MOTS-C
Mitochondrial open reading frame of the 12S rRNA-c
A mitochondrial-derived peptide research material studied in cellular energy-sensing, metabolic and osteogenic model systems.
CatalogMOTS-PW
ManufacturerRemetide
PurityTarget ≥99% by RP-HPLC; lot result controls
PackResearch pack · supplied amount shown on product record
Price range: $43.00 through $114.00 — or from Original price was: $43.00.$36.55Current price is: $36.55. / month Current catalog price; lot availability controls fulfillment.
AvailabilityIn stock
Subscribe monthly and save 15%$36.55 per delivery. The same price applies to the first order and recurring renewals.
- Guest checkout
- All major cards
- COA per lot
- 2-day shipping
- Cancel anytime
MOTS-C$43.00COA available
01Lot documentationCOA and analytical-record model
02Defined specificationMethod and result remain lot specific
03Tracked fulfillmentShipping method and lot allocation confirmed at order review
04Responsible useNon-clinical laboratory context
Lot documentation
Current Certificate of Analysis
27 approved certificates are attached to this product record.
Reported 2026-10-13Lot MS40-100826-199.18% purity · 44.99 mg
Open COA
Reported 2026-05-23Lot MOTS10-052026-299.42% purity · 11.09 mg
Open COA
View all historical COAs (24)
Reported 2026-05-14Lot MOT10-052026-499.76% purity · 12.07 mg
Open COA
Reported 2026-05-14Lot MOT40-052026-199.59% purity · 41.71 mg
Open COA
Reported 2026-05-14Lot MOTS10-052026-799.61% purity · 13.96 mg
Open COA
Reported 2026-05-14Lot MOT10-052026-199.59% purity · 12.23 mg
Open COA
Reported 2026-05-08Lot MOT10-052026-299.78% purity · 11.06 mg
Open COA
Reported 2026-05-08Lot MOT10-052026-299.78% purity · 11.06 mg
Open COA
Reported 2026-04-25Lot MOT40-042026-499.36% purity · 40.48 mg
Open COA
Reported 2026-04-25Lot MOT40-042026-499.36% purity · 40.48 mg
Open COA
Reported 2026-04-22Lot MOTS10-042026-299.57% purity · 10.07 mg
Open COA
Reported 2026-04-12Lot MOT10-042026-499.22% purity · 12.00 mg
Open COA
Reported 2026-03-07Lot MOT10-032026-1 (black cap)99.27% purity · 10.32 mg
Open COA
Reported 2026-03-07Lot MOT10-032026-1 (purple cap)99.42% purity · 10.29 mg
Open COA
Reported 2025-12-31Lot MOTS12292025-J99.026% purity · 10.10 mg
Open COA
Reported 2025-12-17Lot 12152025-J99.729% purity · 10.86 mg
Open COA
Reported 2025-12-05Lot MOT1011242025-1299.657% purity · 9.70 mg
Open COA
Reported 2025-11-23Lot MOTS1192025-J99.327% purity · 9.93 mg
Open COA
Reported 2025-10-30Lot MOTS101024202S-1399.769% purity · 10.81 mg
Open COA
Reported 2025-10-16Lot MOTS1042025-H99.42% purity · 11.65 mg
Open COA
Reported 2025-10-15Lot MOT1010102025-1199.299% purity · 11.20 mg
Open COA
Reported 2025-10-09Lot MOT1009242025-1099.06% purity · 10.44 mg
Open COA
Reported 2025-09-25Lot MOT100918025-0999.128% purity · 13.05 mg
Open COA
Reported 2025-08-05Lot MOT1073022025-0999.52% purity · 11.98 mg
Open COA
Reported 2025-07-11Lot MOTS1007202S-N99.3% purity · 10.46 mg
Open COA
Reported 2025-06-15Lot N-MOT1006112025-0799.08% purity · 10.01 mg
Open COA
Technical information
Chemical & material record
Presented in a scientific-catalog format so the material can be evaluated by identity, form and documentation before purchase.
- Identity
- MOTS-c research peptide
- Synonyms
- Mitochondrial open reading frame of the 12S rRNA-c
- CAS number
- See approved salt-form specification
- Molecular formula
- See approved salt-form specification
- Formula weight
- See approved salt-form specification
- Sequence / identity note
- Sequence disclosed in the controlled technical record
- Manufacturer
- Remetide
- Manufacturing role
- Custom peptide synthesis and manufacture
- Form
- Lyophilized, non-sterile research material
- Purity specification
- Target ≥99% by RP-HPLC; lot result controls
- Storage
- -20°C, dry and protected from light; follow lot documentation
- Pack size
- Research pack · supplied amount shown on product record
- Catalog number
- MOTS-PW
Research context
Published research & product context
Published literature is presented separately from lot-specific identity, purity and analytical results.
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region. Published research has examined its relationship to folate and purine metabolism, AMP-activated protein kinase (AMPK) signaling and cellular glucose utilization.
In HEK293 cells, MOTS-c was reported to increase AICAR accumulation, activate AMPK and increase glycolysis in an AMPK-dependent manner. At 1 µM, it increased osteogenic differentiation and calcified-nodule formation in rat bone-marrow mesenchymal stem cells. Animal studies have explored metabolic and cardiovascular endpoints.
Selected published findings
- Associated with AICAR accumulation, AMPK activation and AMPK-dependent glycolysis in HEK293 cells.
- Examined for osteogenic-differentiation endpoints in rat bone-marrow mesenchymal stem cells.
- Was evaluated in non-clinical metabolic and cardiovascular models.
References and product citations 3
- Lee, C., Drew, B.G., Sallam, T., et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 21(3), 443–454 (2015).
- Hu, B.T., and Chen, W.Z. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. European Review for Medical and Pharmacological Sciences 22(21), 7156–7163 (2018).
- Wei, M., Gan, L., Liu, Z., et al. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via AMPK signaling. Cardiorenal Medicine 10(1), 42–50 (2020).
Literature interpretation: This summary describes published experimental literature and is not a lot specification, clinical claim, use instruction or representation that the supplied research material will reproduce a published result. This record intentionally excludes dosing, administration, clinical outcomes, patient eligibility and therapeutic comparisons.
Intended laboratory context
Illustrative applications
- Analytical comparison
- Method development
- In-vitro laboratory investigation
- Research protocol development
Documentation package
Documentation
- PDFCertificate of AnalysisSample
- PDFHPLC chromatogramSample
- PDFMass-spectrometry summarySample
- PDFHandling statementSample
For laboratory research workflows only. Not for administration to humans or animals and not supplied with dosing or reconstitution guidance.
FAQ
Research procurement FAQ
Plain answers about research-use boundaries, documentation, accounts, and ordering. Not medical or clinical guidance.
What is this product record for?
MOTS-C is presented as a research catalog record with identity, format, pack options, specification language, and lot-documentation pathways for qualified laboratory procurement. It is not a consumer or clinical product.
How do I order this item?
Open the product record, choose the pack option, and check out as a guest (no account needed) or signed in. If the item is quotation-only (bulk API or custom project), use the quotation pathway instead of standard cart checkout.
What does “research use only” mean?
Research use only (RUO) means these materials are intended for legitimate non-clinical laboratory investigation. They are not offered for human or animal administration, compounding, diagnosis, treatment, prevention, or consumer use.
Do I need an account to browse or buy?
No. Guest checkout is open: you can browse the catalog and order without creating an account. Subscribe & Save orders get an account created automatically so you can manage or cancel the subscription. Lot documentation stays tied to every order either way.
What documentation accompanies a research material?
Lot-level documentation may include a Certificate of Analysis (COA), identity/purity method context, and related analytical records. Always defer to the approved lot record and material specification for the specific shipment.
How is purity described?
Purity statements identify the analytical method (for example RP-HPLC) and defer to the released lot result and any molecule-specific specification. Public copy never replaces the lot COA.
How does shipping work for research materials?
Shipping follows the carrier and packaging appropriate for the material specification. Inspect shipments promptly and contact support with the order number, catalog number, and lot if anything looks incorrect. Unauthorized returns of research materials are not accepted.
Does Simple Life Science provide dosing or medical guidance?
No. We do not provide dosing, administration, medical advice, patient selection, or clinical-use instructions. Website content and technical support stay within laboratory research context.
Need a current record?
Documentation before decision-making.
Reference MOTS-PW and the applicable lot when contacting technical support. Published files support evaluation but do not replace the approved lot COA or material specification.
View documentation model
