Intended laboratory context
Illustrative applications
- Analytical comparison
- Method development
- In-vitro laboratory investigation
- Research protocol development
Lyophilized Peptides
MOTS-C
Mitochondrial open reading frame of the 12S rRNA-c
A mitochondrial-derived peptide research material studied in cellular energy-sensing, metabolic and osteogenic model systems.
CatalogMOTS-PW
ManufacturerRemetide
PurityProposed ≥99% by RP-HPLC; lot result controls
PackResearch pack · supplied amount shown on product record
Price range: $43.00 through $114.00 Current catalog price; lot availability controls fulfillment.
AvailabilityIn stock
For laboratory research use only. Not for human or veterinary use.
MOTS-C$43.00 – $114.00Price range: $43.00 through $114.00
01Lot documentationCOA and analytical-record model
02Defined specificationMethod and result remain lot specific
03Tracked fulfillmentShipping method and lot allocation confirmed at order review
04Responsible useNon-clinical laboratory context
Technical information
Chemical & material record
Presented in a scientific-catalog format so the material can be evaluated by identity, form and documentation before purchase.
- Identity
- MOTS-c research peptide
- Synonyms
- Mitochondrial open reading frame of the 12S rRNA-c
- CAS number
- See approved salt-form specification
- Molecular formula
- See approved salt-form specification
- Formula weight
- See approved salt-form specification
- Sequence / identity note
- Sequence disclosed in the controlled technical record
- Manufacturer
- Remetide
- Manufacturing role
- Custom peptide synthesis and manufacture
- Form
- Lyophilized, non-sterile research material
- Purity specification
- Proposed ≥99% by RP-HPLC; lot result controls
- Storage
- -20°C, dry and protected from light; follow lot documentation
- Pack size
- Research pack · supplied amount shown on product record
- Catalog number
- MOTS-PW
Product description
Published context, clearly separated from lot claims.
A technical catalog should make the chemical record, relevant experimental literature and product-specific documentation independently reviewable.
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region. Published research has examined its relationship to folate and purine metabolism, AMP-activated protein kinase (AMPK) signaling and cellular glucose utilization.
In HEK293 cells, MOTS-c was reported to increase AICAR accumulation, activate AMPK and increase glycolysis in an AMPK-dependent manner. At 1 µM, it increased osteogenic differentiation and calcified-nodule formation in rat bone-marrow mesenchymal stem cells. Animal studies have explored metabolic and cardiovascular endpoints.
Selected published findings
- Associated with AICAR accumulation, AMPK activation and AMPK-dependent glycolysis in HEK293 cells.
- Examined for osteogenic-differentiation endpoints in rat bone-marrow mesenchymal stem cells.
- Was evaluated in non-clinical metabolic and cardiovascular models.
References and product citations 3
- Lee, C., Drew, B.G., Sallam, T., et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism 21(3), 443–454 (2015).
- Hu, B.T., and Chen, W.Z. MOTS-c improves osteoporosis by promoting osteogenic differentiation of bone marrow mesenchymal stem cells via TGF-β/Smad pathway. European Review for Medical and Pharmacological Sciences 22(21), 7156–7163 (2018).
- Wei, M., Gan, L., Liu, Z., et al. Mitochondrial-derived peptide MOTS-c attenuates vascular calcification and secondary myocardial remodeling via AMPK signaling. Cardiorenal Medicine 10(1), 42–50 (2020).
Literature interpretation: This summary describes published experimental literature and is not a lot specification, clinical claim, use instruction or representation that the supplied research material will reproduce a published result. This record intentionally excludes dosing, administration, clinical outcomes, patient eligibility and therapeutic comparisons.
Proposed package
Documentation
- PDFCertificate of AnalysisSample
- PDFHPLC chromatogramSample
- PDFMass-spectrometry summarySample
- PDFHandling statementSample
For laboratory research workflows only. Not for administration to humans or animals and not supplied with dosing or reconstitution guidance.
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Documentation before decision-making.
Reference MOTS-PW and the applicable lot when contacting technical support. Published files support evaluation but do not replace the approved lot COA or material specification.
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