{"id":156,"date":"2026-09-01T02:59:05","date_gmt":"2026-09-01T02:59:05","guid":{"rendered":"https:\/\/simplepeparchi.wpenginepowered.com\/product\/gut-inflammation-research-bpc-kpv-larazotide\/"},"modified":"2026-10-04T10:23:11","modified_gmt":"2026-10-04T14:23:11","slug":"gut-inflammation-research-bpc-kpv-larazotide","status":"publish","type":"product","link":"https:\/\/simplelifescience.com\/es\/product\/gut-inflammation-research-bpc-kpv-larazotide\/","title":{"rendered":"Gut Inflammation Research (BPC\/KPV\/Larazotide)"},"content":{"rendered":"<div class=\"product-container\">\n<h1>Simple Peptide Triple-Action Oral Peptide Compound: BPC-157, KPV, and Larazotide Acetate<\/h1>\n<div class=\"disclaimer\">\n<p><strong>Strictly for Laboratory and Research Applications Only.<\/strong><\/p>\n<p>This compound is sold exclusively for in-vitro experiments, testing, and scientific study. Not intended for use as a component of, or supplement to, any finished product intended for distribution to, or consumption by, individuals.<\/p>\n<\/div>\n<p>This tripartite compound offers a formulation of three distinct gut-active peptides for models investigating gastrointestinal integrity and repair. This blend features compounds engaging three core processes: tissue structure maintenance, inflammation control, and barrier regulation.<\/p>\n<h2>Compound Overview<\/h2>\n<p>The oral capsule formulation combines three complementary peptide chemistries:<\/p>\n<ul>\n<li><strong>BPC-157 (Body Protection Compound-157):<\/strong> A pleiotropic cytoprotective and angiogenic pentadecapeptide.<\/li>\n<li><strong>KPV (Lysine-Proline-Valine):<\/strong> An anti-inflammatory tripeptide derived from alpha-melanocyte stimulating hormone (alpha-MSH).<\/li>\n<li><strong>Larazotide Acetate:<\/strong> A tight junction regulatory octapeptide that functions as a zonulin antagonist.<\/li>\n<\/ul>\n<h2>BPC-157 (Body Protection Compound-157)<\/h2>\n<p>BPC-157 is a synthetic 15-amino acid pentadecapeptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, 1,419 Da). Isolated from a protective protein in gastric juice, BPC-157 exhibits unique molecular architecture that confers resistance to degradation, remaining intact for over 24 hours in acidic conditions, a property enabling oral delivery in experimental systems.<\/p>\n<h3>Observed Mechanisms in Biological Systems:<\/h3>\n<ul>\n<li><strong>Angiogenesis and Vascular Repair:<\/strong> Stimulates vascular endothelial growth factor receptor-2 (VEGFR2) and enhances nitric oxide (NO) signaling through the Akt-eNOS pathway. This mechanism facilitates endothelial proliferation and new capillary formation in ischemic tissue models.<\/li>\n<li><strong>Cellular Proliferation:<\/strong> Induces ERK1\/2 phosphorylation in endothelial cell lines, promoting proliferation and migration. Activation of transcription factors like EGR-1 regulates genes associated with extracellular matrix remodeling.<\/li>\n<li><strong>Inflammation Resolution:<\/strong> Decreases expression of pro-inflammatory cytokines (TNF-alpha, IL-6, IFN-gamma) and drives macrophage phenotype shifting from pro-inflammatory (M1) toward reparative (M2).<\/li>\n<li><strong>Neuromuscular Stability:<\/strong> Exhibits regulatory effects on neurotransmitter systems (dopamine, serotonin, GABA) and preserves neuromuscular junction function in relevant studies.<\/li>\n<\/ul>\n<h2>KPV (Lysine-Proline-Valine)<\/h2>\n<p>KPV is a naturally occurring tripeptide that corresponds to the C-terminal sequence of alpha-MSH. It retains the anti-inflammatory efficacy of the parent hormone without inducing melanotropic effects.<\/p>\n<h3>Observed Mechanisms in Biological Systems:<\/h3>\n<ul>\n<li><strong>NF-kB Inhibition:<\/strong> Primary anti-inflammatory action involves inhibiting Nuclear Factor kappa B (NF-kB) by blocking p65 RelA nuclear transport, thereby preventing transcription of key pro-inflammatory cytokines (e.g., TNF-alpha, IL-1beta).<\/li>\n<li><strong>Active Cellular Uptake:<\/strong> Demonstrates active transport into intestinal epithelial and immune cells via the di\/tripeptide transporter PepT1. This transporter is known to be upregulated in models of intestinal inflammation, potentially allowing targeted research activity at the cellular level.<\/li>\n<\/ul>\n<h2 id=\"clinical-studies\">Referenced Human Studies and Clinical Trials (BPC-157)<\/h2>\n<p>The compound&#8217;s activity profile has led to formal investigations in human subjects. These studies are cited for informational purposes and should not be misconstrued as an endorsement for non-research use.<\/p>\n<ul>\n<li>Initial safety trials (PL-10, PLD-116, PL14736) were conducted in Croatia, evaluating administration in subjects with inflammatory bowel disease, confirming a safe profile for gastrointestinal applications.<\/li>\n<li>A Phase I safety and pharmacokinetics study (PCO-02 \/ Bepecin) was registered: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02637284\">NCT02637284<\/a> (Spain, 2015-2016).<\/li>\n<li>A currently registered Phase 2 randomized, double-blind, placebo-controlled trial is evaluating subcutaneous BPC-157 for acute hamstring strain: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT07437547\">NCT07437547<\/a> (China, 2026).<\/li>\n<li>Small human pilot studies have been published, including a retrospective open-label study on intra-articular administration for knee discomfort, where 87.5% of subjects reported significant pain relief.<\/li>\n<li>A pilot study investigated intravesical injections in subjects with treatment-resistant moderate-to-severe interstitial cystitis, with all 12 subjects reporting 80-100% resolution of symptoms at 6 weeks.<\/li>\n<\/ul>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Advanced mechanistic complement of three gut-active peptides: BPC-157 for cytoprotection and angiogenesis, KPV for NF-\u03baB inhibition, and Larazotide for tight junction regulation.<\/p>","protected":false},"featured_media":773,"comment_status":"open","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":""},"product_brand":[],"product_cat":[63,64,31,42,51,25],"product_tag":[],"class_list":["post-156","product","type-product","status-publish","has-post-thumbnail","product_cat-classification-capsules","product_cat-classification-closeout_products","product_cat-classification-immunomodulatory-peptides","product_cat-classification-new-arrivals","product_cat-classification-oral-peptides","product_cat-orals","has-subscription-plans","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product\/156","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/comments?post=156"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/media\/773"}],"wp:attachment":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/media?parent=156"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_brand?post=156"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_cat?post=156"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_tag?post=156"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}