{"id":155,"date":"2026-09-01T02:59:04","date_gmt":"2026-09-01T02:59:04","guid":{"rendered":"https:\/\/simplepeparchi.wpenginepowered.com\/product\/epitalon-1mg\/"},"modified":"2026-10-05T22:33:49","modified_gmt":"2026-10-06T02:33:49","slug":"epitalon-1mg","status":"publish","type":"product","link":"https:\/\/simplelifescience.com\/es\/product\/epitalon-1mg\/","title":{"rendered":"Epitalon 1mg"},"content":{"rendered":"<div class=\"product-info-container\">\n<div class=\"product-short-description\">\n<p>Epitalon (AEDG) synthetic tetrapeptide research compound (Ala-Glu-Asp-Gly). Subject of studies exploring telomerase activation and telomere maintenance.<\/p>\n<\/div>\n<div class=\"product-full-description\">\n<h1 class=\"seo-title\">Epitalon (AEDG) Tetrapeptide Bioregulator | Simple Peptide Research<\/h1>\n<p>Epitalon (AEDG) is a synthetic pineal tetrapeptide (C\u2081\u2084H\u2082\u2082N\u2084O\u2089), approximately 390 Da. This low molecular weight is a factor in research focusing on oral bioavailability for compound delivery.<\/p>\n<h2>Core Research Mechanisms:<\/h2>\n<ul>\n<li><strong>Telomere Dynamics:<\/strong> Confirmed hTERT activation and telomere elongation in human somatic cells; independently verified in human fibroblast and epithelial lines.<\/li>\n<li><strong>Epigenetic Regulation:<\/strong> Binds to DNA\/linker histones, regulating chromatin architecture and transcription in aged lymphocyte cultures. Regulates neuronal differentiation gene expression in human stem cells.<\/li>\n<li><strong>Neuroendocrine Signaling:<\/strong> In senescent rhesus monkeys (<em>Macaca mulatta<\/em>), administration stimulated evening melatonin production and normalized the circadian cortisol rhythm.<\/li>\n<\/ul>\n<h2>Preclinical &amp; Clinical Findings:<\/h2>\n<p>Preclinical data show maximum lifespan extension of 42% in CBA mice and 11-16% in <em>Drosophila melanogaster<\/em>.<\/p>\n<p>Limited human investigations (using Epitalon or Epithalamin):<\/p>\n<ol>\n<li>A 15-year <a href=\"https:\/\/khavinson.info\/assets\/files\/skan\/2022-trofimova_khavinson_trofimov.pdf\">cardiovascular study<\/a> reported a significant reduction in cardiovascular mortality risk and 26.7% improvement in 15-year survival in elderly patients.<\/li>\n<li>A <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12195242\/\">clinical investigation<\/a> reported a 90% positive clinical effect in human patients with degenerative retinal lesions (retinitis pigmentosa).<\/li>\n<\/ol>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Epitalon (AEDG) synthetic tetrapeptide research compound (Ala-Glu-Asp-Gly). Subject of studies exploring telomerase activation and telomere maintenance.<\/p>","protected":false},"featured_media":772,"comment_status":"open","ping_status":"closed","template":"","meta":{"_yoast_wpseo_title":"","_yoast_wpseo_metadesc":"","_yoast_wpseo_focuskw":""},"product_brand":[],"product_cat":[63,64,49,36,42,51,25],"product_tag":[],"class_list":["post-155","product","type-product","status-publish","has-post-thumbnail","product_cat-classification-capsules","product_cat-classification-closeout_products","product_cat-classification-longevity","product_cat-classification-anti-aging-peptides","product_cat-classification-new-arrivals","product_cat-classification-oral-peptides","product_cat-orals","has-subscription-plans","first","instock","taxable","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product\/155","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/comments?post=155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/media\/772"}],"wp:attachment":[{"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/media?parent=155"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_brand?post=155"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_cat?post=155"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/simplelifescience.com\/es\/wp-json\/wp\/v2\/product_tag?post=155"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}